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. 2023 Jan 8;15(1):183. doi: 10.3390/v15010183

Figure 1.

Figure 1

Life cycle of hepatitis C virus (HCV) and mechanism of HCV acute exacerbation and direct-acting antivirals (DAA). Candidates of HCV receptors: glycosaminoglycans, GAGs; low-density lipoprotein receptor, LDL-R; scavenger receptor class B type I, SR-BI; claudin-1, CLDN1; occludin, OCLN; epidermal growth factor receptor, EGFR; ephrin receptor A2, EphA2; transferrin receptor 1, TfR1; Niemann–Pick C1-like 1, NPC1L1. IRES, internal ribosomal entry site; UTR, untranslated region; C, core; E1 and E2, envelope glycoproteins 1 and 2; p7, transmembrane protein 7; NS, nonstructural protein. See the references [75,89].