Table 1.

Summary template format for summarising a risk assessment of combined exposure to multiple chemicals using a component-based approach (modified from [2]).

Problem Formulation	Description of the Components in the Mixture	Chemical Space to Be Covered, Composition, Data Availability for Components
	Conceptual model	Question/Terms of Reference, Source, exposure pathways, Species/subpopulation, Regulatory framework, Other?
	Methodology	Overview of available data Component-based approach Principles for grouping and Assessment Group(s)
	Analysis plan
Exposure Assessment	Components of the assessment group
	Summary occurrence (concentration) data
	Summary exposure	Assumptions, Exposure metrics
		Identify uncertainties
Hazard Identification and Hazard Characterisation	Component-based approach
	Reference points/Reference values
	Summary hazard metrics	Assumptions combined toxicity (Dose addition, response addition, interactions) Hazard metrics
		Identify uncertainties
Risk Characterisation	Summary exposure and hazard metrics
	Risk characterisation approach
	Summary risk metrics	Associated Assumptions (Dose addition, response addition, interactions), Risk metrics
		Overall uncertainty analysis
	Interpretation