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. 2023 Jan 16;24(2):1775. doi: 10.3390/ijms24021775

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ATP13A2 silencing alters the circadian defect of flies expressing mutant α-syn. Locomotor activity and anticipation of the dark–light transition of young (0–3-day-old) and old (30-day-old) flies expressing WT, A30P, and A53Tα-syn with and without ATP13A2 silencing were studied using a Drosophila activity monitor (DAM) (A) and the corresponding Eduction graph is presented (B). Dark (12 h) and light (12 h) phases were indicated as D and L, respectively. Group activity (counts/min) was also shown. A30P and A53T flies (young and old) showed defective evening light expectancy, as indicated by * (A,B).