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. 2023 Jan 13;24(2):1564. doi: 10.3390/ijms24021564

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of some of the indirect bidirectional interactions between MCs and CD8 T cells. The communication between MCs and CD8 T cells can be realised by soluble mediators. Chemokine–chemokine ligand interactions can provide instructive signals for CD8 T cells. For example, CCL5-CCR5 and CXCL9/10/11-CXCR3 binding can promote cell migration to Th1-type inflammatory sites, while the latter also plays a role in cell activation and differentiation. TGF-β-TGF-βR signals can promote CD8 T cell residency in skin.