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Costimulatory molecules and their ligands in skin disorders.
| CD8 T Cell Receptors |
MC Ligands | Receptor Family | Disease | Ref. |
|---|---|---|---|---|
| CD28 | CD80 (B7-1); CD86 (B7-2) | IgG-CD28/B7 | psoriasis | [117] |
| OX40 (CD134) | OX40L (CD252) | TNF/TNFR | atopic dermatitis; alopecia areata |
[33,118] |
| 4-1BB (CD137) | 4-1BBL | TNF/TNFR | psoriasis | [119] |
Abbreviations: MC, mast cells; Ig, immunoglobulin; TNF, tumour necrosis factor; TNFR, tumour necrosis factor receptor.
