Table 1.
MTT Assay Data (72-h) and logP Values for Small Molecule-Carbohydrate Analogues.
| Compound | SUM159 IC50 (µM) | MDA-MB-231 IC50 (µM) | logP |
|---|---|---|---|
| Bazedoxifene | 7.1 ± 1.1 | 12 ± 2 | 6.01 |
| LS-TX-2 | Inactive 1 | Inactive 2 | 1.92 |
| LS-TX-3 | Inactive 1 | Inactive 2 | 1.92 |
| LS-TX-4 | Inactive 1 | Inactive 2 | 1.92 |
| LS-TF-2P | 41 ± 5.4 | 96 ± 1.6 | 4.39 |
| LS-TF-3P | 16 ± 0.8 | 28.7 ± 2.1 | 4.39 |
| LS-TF-4P | 26.1 ± 3.8 | 18.4 ± 5.5 | 4.39 |
| LS-TG-2P | 6.9 ± 0.2 | 10.5 ± 0.3 | 2.30 |
| LS-TG-3P | 14.8 ± 1.3 | 49.4 ± 1.4 | 2.30 |
| LS-TG-4P | 2.5 ± 0.3 | 27.6 ± 4.8 | 2.30 |
| LS-TX-2P | 12.4 ± 0.8 | 27.4 ± 1.6 | 2.61 |
| LS-TX-3P | 20.8 ± 4.6 | 60.6 ± 2.0 | 2.61 |
| LS-TX-4P | 10.6 ± 0.8 | 32.2 ± 2.9 | 2.61 |
| LS-AF-2P | 103 ± 6.1 | 196 ± 8.4 | 3.43 |
| LS-AF-3P | 44 ± 3.7 | h86 ± 7 | 3.43 |
| LS-AF-4P | 18.1 ± 1.3 | 59.3 ± 7.4 | 3.43 |
IC50 ± SE. logP values calculated using ChemDraw 18.1. 1 Inactive up to the highest tested concentration of 20 µM. 2 Inactive up to the highest tested concentration of 50 µM.