. 2023 Jan 12;24(2):1506. doi: 10.3390/ijms24021506

Table 3.

miRNAs involved in the pathogenesis of lung cancer.

miRNA	Genetic Location	Target	Mechasims	References
miR-7	miR-7 is derived from three precursors: pri-miR-7-1 (9q21), pri-miR-7-2 (15q26) and andpri-miR-7-3 (19q13)	EGFR	Sustaining proliferative signaling	[139,140]
miR-27	19p13.12	EGFR	Sustaining proliferative signaling	[141,142,143,144]
miR-30	6q13	EGFR	Sustaining proliferative signaling	[145,146,147]
miR-34	1p36.22	EGFR	Sustaining proliferative signaling	[148,149,150]
miR-34	1p36.22	PD-L1	Avoiding immune destruction and tumors promoting inflammation	[148,149,150]
miR-128	2q21.3	EGFR	Sustaining proliferative signaling	[151,152,153,154]
miR-128	2q21.3	VEGF	Inducing angiogenesis	[151,152,153,154]
miR-134	14q32.31	EGFR	Sustaining proliferative signaling	[155,156,157]
miR-542	Xq26.3	EGFR	Sustaining proliferative signaling	[158,159,160]
miR-1258	2q31.3	Grb2	Sustaining proliferative signaling	[161,162,163]
miR-148a	7p15.2	SOS	Sustaining proliferative signaling	[164,165,166]
miR-181a	chromosome 1 (37.p5)	RAS	Sustaining proliferative signaling	[167,168]
miR-193a	17q11.2	RAS	Sustaining proliferative signaling	[169,170,171]
miR-760	1p22.1	ROS1	Sustaining proliferative signaling	[172,173,174]
miR-96	7q32.2	EML4-ALK	Sustaining proliferative signaling	[175,176,177]
miR-200c/	12p13.31	PI3K	Sustaining proliferative signaling	[178,179,180,181,182]
miR-200c/	chromosome 1	ZEB1/2	Activating invasion and metastasis
miR-200		VEGF	Inducing angiogenesis
miR-200		PD-L1	Avoiding immune destruction and tumors promoting inflammation
miR-520a	19q13.42	PI3K	Sustaining proliferative signaling	[183,184,185]
miR-641	19q13.2	MDM2	Evading growth suppressors	[186,187,188]
miR-660	Xp11.23	MDM2	Evading growth suppressors	[189,190]
miR-15a	13q14.2	CDK/Cyclin	Evading growth suppressors	[191,192,193]
miR-16	13q14	CDK/Cyclin	Evading growth suppressors	[194,195,196,197]
miR-16	13q14	Bcl	Resisting cell death	[194,195,196,197]
miR-449a	5q11.2	E2F	Evading growth suppressors	[198,199,200,201]
miR-299	14q32.31	hTERT	Enabling replicative immortality	[202,203,204]
miR-491	9p21.3	hTERT	Enabling replicative immortality	[205,206,207]
miR-512	19q13.42	hTERT	Enabling replicative immortality	[208,209,210]
miR-29	7q32.3	DNMT	Enabling replicative immortality	[211,212,213]
miR-146A	5q33.3	Smad	Activating invasion and metastasis	[214,215,216]
miR-21	17q23.1	TGF-β	Activating invasion and metastasis	[217,218,219,220,221]
miR-21	17q23.1	PTEN	Avoiding immune destruction and Tumors promoting inflammation	[217,218,219,220,221]
miR-23	no data	TGF-β	Activating invasion and metastasis	[222,223,224]
miR-99A	21q21.1	TGF-β	Activating invasion and metastasis	[225,226,227]
miR-155	21q21.3	TGF-β	Activating invasion and metastasis	[228,229,230,231]
miR-192	11q13.1	TGF-β	Activating invasion and metastasis	[232,233,234,235]
miR-115	no data	TGF-β	Activating invasion and metastasis	[236,237]
miR-520	19q13.42	TGF-β	Activating invasion and metastasis	[238,239,240]
miR-497	17p13.1	HDGF	Inducing angiogenesis	[241,242,243,244]
miR-494	14q32.31	PTEN	Inducing angiogenesis	[245,246,247,248]
miR-126	9q34.3	VEGF	Inducing angiogenesis	[249,250,251,252]
miR-33b	17p11.2	LDHA	Deregulating cellular energetics	[253,254,255]
miR-144	17q11.2	GLUT	Deregulating cellular energetics	[256,257,258]
miR-124	8p23.1	Akt	Deregulating cellular energetics	[259,260,261]
miR-199a	19p13.2	HIF-1	Deregulating cellular energetics	[262,263,264]
miR-31-5p	9p21.3	FIH	Deregulating cellular energetics	[265,266,267]
miR-28	3q28	PD-1PTEN	Avoiding immune destruction and tumors promoting inflammation	[268,269,270]
miR-138	16q13	PD-1	Avoiding immune destruction and tumors promoting inflammation	[271,272]
miR-138	16q13	PD-L1		[271,272]
miR-197	1p13.3	CKS1B	Avoiding immune destruction and tumors promoting inflammation	[273,274,275]
miR-513	Xq27.3	PD-L1	Avoiding immune destruction and tumors promoting inflammation	[276,277,278,279]
miR-20	13q31.3	PTEN	Avoiding immune destruction and tumors promoting inflammation	[280,281,282]
miR-130	11q12.1	PTEN	Avoiding immune destruction and tumors promoting inflammation	[283,284,285]
miR-424	Xq26.3	CD80	Avoiding immune destruction and tumors promoting inflammation	[286,287,288,289]
miR-136	14q32.2	CTLA-4	Avoiding immune destruction and tumors promoting inflammation	[290,291,292,293]
miR-301b	22q11.21	BH3	Resisting cell death	[294,295,296,297,298]

Abbreviations: EGFR—epidermal growth factor receptor; PD-L1—programmed death-ligand 1; VEGFA—vascular endothelial growth factor A; Grb2—growth factor receptor bound protein 2; SOS—Ras/Rac guanine nucleotide exchange factor; Ras—rat sarcoma virus; ROS1—ROS proto-oncogene 1, receptor tyrosine kinase; EML4—echinoderm microtubule-associated protein-like 4; ALK—anaplastic lymphoma kinase; PI3K—phosphoinositide 3-kinase; ZEB1 zinc finger E-box binding homeobox 1; MDM2—mouse double minute 2 homolog; CDK—cyclin-dependent kinase; Bcl—B-cell lymphoma; hTERT—telomerase reverse transcriptase; DNMT—DNA methyltransferase; SMAD—suppressor of mothers against decapentaplegic; TGF-β—transforming growth factor beta; PTEN—phosphatase and tensin homolog; HDGF—heparin binding growth factor; LDHA—lactate dehydrogenase A; GLUT—glucose transporter; HIF-1—hypoxia inducible factor 1 subunit alpha; FIH—hypoxia-inducible factor inhibitor; CKS1B—CDC28 protein kinase regulatory subunit 1B; CD80—cluster of differentiation 80; CTLA-4—cytotoxic T cell antigen 4; BH3—interacting domain death agonist.