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. 2023 Jan 6;15(1):202. doi: 10.3390/pharmaceutics15010202

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism of action of leriglitazone. The beneficial effects of leriglitazone that have been confirmed in the current study on the hiPS-derived astrocytes from PKAN patients are indicated with an asterisk *: leriglitazone enhanced respiratory activity, decreased iron accumulation and increased astrocyte survival. Moreover, leriglitazone decreased oxidative stress, increased mitochondrial biogenesis and decreased inflammation as reported in other preclinical studies. All these effects could lead to an improvement of mitochondrial function resulting in neuroprotection and increased astrocyte survival.