Table 1.

Studies evaluating the efficacy and safety of Metformin in male patients affected by acne (GAGS: Global Acne Grading System, HOMA-IR: homeostasis model assessment-insulin resistance).

Study	Population		Mean Age—Year			Metformin		GAGS		HOMA-IR			BMI kg/m2			Plasma Insulin, μIU/mL			Total Cholesterol mg/dL		HDL Cholesterol mg/dL
	Case	Control	Case	Control	p Value	Case	Control	Case	Control	Case	Control	p Value	Case	Control	p Value	Case	Control	p Value	Case	Control	Case	Control
Robinson et al., 2019 [37]	42 (35.7% male)	42 (23.8% male)	22.6	23.2	0.501	Yes		N/A	N/A	1.6	1.8	0.295	21.6	22.6	0.303	7.4	8.2	0.468	N/A	N/A	N/A	N/A
Fabbroccini et al. 2016 [46]	10	10	19.5	19.5	N/A	Yes		14 ± 10.4	19.4 ± 7.418	1.5 ± 0.1	1.5 ± 0.8	N/A	22.9 ± 3.5	24.1 ± 2.5	N/A	9.6 ± 7.5	10.4 ± 1.6	N/A	165 ± 4.8	166 ± 14.5	49.5 ± 0.5	50 ± 0.4