Table 2.

PEI-based drug delivery system for cancer treatment.

Therapeutic Modalities	Therapeutic Agents	Cell Line Models	In Vivo Models	Ref.
Chemotherapy	DOX	HeLa	HeLa	[57]
	MTX	HCT 116	/	[138]
	PTX	HepG2	/	[139]
	DOX	C6	/	[140]
	DOX	HeLa	HeLa	[143]
	DOX	4T1, HepG2	/	[149]
	DOX	A549	/	[142]
	DOX, siRNA	MDA-MB-231, HeLa, EAT	EAT	[150]
	DOX	SKBR3	SKBR3	[151]
Gene therapy	pDNA	HeLa, 16HBE14o−, HepG2	/	[144]
	pDNA	Huh7	Huh7	[145]
	DNA	NIH/3T3	/	[45]
	pDNA	HeLa	/	[51]
	DNA	HeLa, CT26	CT26	[148]
	mRNA	B16-OVA	B16-OVA	[152]
Other therapies	RNase A	MDA-MB-231	/	[153]
	Oxidized mesoporous carbon nanospheres, pDNA	MCF-7	MCF-7	[154]
	CAT-Ce6	T24	T24	[155]
	GO, DTX, anti-miRNA21	MDA-MB-231	/	[156]
	CuS, DTX, CpG	4T1	4T1	[157]
	pDNA, 9B9 mAb	SMMC-7721	SMMC-7721	[158]