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Proposed schematic models of interfacial binding of four different families of PLA2s. HDX-MS technique was used to study the interaction of monomers of different PLA2s bound to membranes, using crystal structures of (A) group IA sPLA2 (PDB- 1PSH), (B) group IV cPLA2 (PDB- 1CJY), (C) group VIA iPLA2 (homology model based on lipase patatin structure, PDB- 1OXW) and (D) group VIIA Lp-PLA2 (PBD- 3D5E). Reprinted from [59].
