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. 2023 Jan 10;24(2):1353. doi: 10.3390/ijms24021353

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Physiologic role of phospholipases in GI tract. Pancreatic sPLA2-IB is secreted in pancreatic juice as a zymogen and activated by trypsin or plasmin in the intestinal lumen. sPLA2-X is secreted by the enterocytes of the intestinal lumen. Both pancreatic sPLA2-IB and enterocytic sPLA2-X hydrolyze dietary and bile-secreted phospholipids. Phospholipase B is secreted in the distal intestine and hydrolyzes the undigested phospholipids yielding glycerylphosphocholine and FAs. Created with BioRender.com.