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. 2023 Jan 11;15(1):204. doi: 10.3390/v15010204

Figure 4.

Figure 4

Strategies to avoid binding of blood proteins to the adenovirus capsid. (a) Chemical shielding. Using polymers linked to the adenovirus, hexon protein can avoid binding of blood proteins. (b) Genetic mutation of the adenovirus hexon protein coding sequence within the adenovirus genome. (c) Complete serotype switch using an alternative adenovirus type not binding blood components. In part created with BioRender.