Table 1.
Overview of the identified adenovirus types [6,7,8]. Summarized are the seven adenovirus species, their general tropism and the receptor type. Vectorized adenovirus types according to PubMed records are underlined.
| Species | Human Adenovirus Types | Tissue Tropism | Receptor (Ad Type) |
|---|---|---|---|
| A | 12, 18, 31, 61 | Intestine | CAR b (12) |
| B | 3, 7, 16, 21, 50, 66, 89, 11, 14, 34, 35, 55, 68, 89, 106, 76–79 | Tonsils and respiratory tract, hematopoietic cells, kidney, urinary bladder | CD46 (3, 7, 11, 14, 16, 21, 34, 35, 50) DSG-2 c (3, 7, 11, 14, 55) HSPG, CD80/86 |
| C | 1, 2, 5 a,f, 6, 57, 104, 108 | Respiratory tract Ad5 infect liver in mouse |
CAR (1, 2, 5, 6), HSPG e MHC-I, VCAM-I, integrins |
| D | 8–10, 13, 15, 17, 19, 20, 22, 23, 24, 25, 26 a, 27, 28, 29, 30, 32, 33, 36, 37, 38, 39, 42, 43–47, 48, 49, 51, 53, 54, 56, 58–60, 62–64, 65, 67, 69, 70, 71, 72, 73–75, 80, 81–88, 90–103, 105, 107, 109–113 | Eye, conjunctive tissues | CAR (9, 10) SA d (8, 19a, 37) CD46 (17, 26, 48, 49) |
| E | 4 | Respiratory tract, eye | CAR |
| F | 40, 41 | Intestine, enterocytes | CAR, HSPG |
| G | 52 | Intestine | CAR, SA |
a Vector types used in the CARS-CoV pandemic; b Coxsackievirus and adenovirus receptor, c DSG2: desmoglein 2, d SA: sialic acid, e HSPG: heparan-sulfate proteoglycan; f most commonly used vector type.