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. 2023 Jan 21;97(3):737–753. doi: 10.1007/s00204-022-03430-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Flow chart of study selection process. The NCBI Geo Database was searched for "Caco-2" or "Caco2" in May 2021, which retrieved 330 data series. Exclusion of 306 data series and inclusion of two (own) data series resulted in a final selection of 29 series linked to 27 unique research papers. After exclusion of five data series because of limited numbers of analyzed genes, studies were divided per manufacturer, of which the Affymetrix platform comprised the largest group with 13 data series corresponding to 13 research papers