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. 2023 Jan 21;13:1200. doi: 10.1038/s41598-023-27962-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of literature mining results for eccDNA-relevant genes and genome instability linked genes known from literature: KEGG pathway enrichment and CHO culture eccDNA genes. (a) Top 30 of the 151 enriched KEGG pathways for the eccDNA-relevant genes texted mined from literature. The node size is proportional to the number of genes found in the pathway, while the node color indicates the pathway’s statistical significance. Pathways with significantly overlapping genes are connected by grey lines. (b) EccDNA-relevant genes identified via literature mining that were also found in CHO culture eccDNA sequences from one or more culture conditions: Day 0 (D0), Control Day 12 (C12), Lactate-stressed Day 12 (ST12). (c) GO biological process enrichment analysis of genome instability linked genes observed on CHO cell eccDNA. Gene ratio reflects the fraction of genes pertaining to a GO term and the color indicates the statistical significance.