Figure 2.

Glycogen particles attach to or detach from the ER membrane. When they connect, then glucose derivatives produced in glycogenolysis enter the luminal compartment of the ER via ER transporters and are further metabolized using the ER membrane enzymes linked to the transporters. In this way, glycogenolysis supplies certain biosynthetic processes in the ER with precursors. Finally, the products of biosynthetic processes are secreted. In addition, the glucose derivatives from glycogenolysis participate in shaping the redox homeostasis of the luminal compartment. Glucose derivatives can enter the pentose phosphate pathway, the operation of which is related to the formation of reduced pyridine nucleotides. The lack of drug glucuronidation affects the amount of GSH in ER. The redox regulation of glycogenolysis connected to the water-soluble antioxidants, GSH and ascorbate can also have various effects.