Table 2.
Association between GPC3 expression and immunohistochemical markers. androgen receptors (AR), progesterone receptors (PR), oestrogen receptors (ER), epidermal growth factor receptors (EGFR), human epidermal growth factor receptor 2 (HER2).
| Immunohistochemical Markers | Negative n = 220 (92.5%) | Positive n = 18 (7.5%) | p Value |
|---|---|---|---|
| AR: | |||
| Negative (n = 106, 44.5%) | 103 (97.2%) | 3 (2.8%) | |
| Positive (n = 132, 55.5%) | 117 (88.6%) | 15 (11.4%) | 0.013 |
| ER: | |||
| Negative (n = 115, 48.3%) | 111 (96.5%) | 4 (3.5%) | |
| Positive (n = 123, 51.7%) | 109 (85.4%) | 14 (14.6%) | 0.009 |
| PR: | |||
| Negative (n = 139, 58.4%) | 134 (96.4%) | 5 (3.6%) | |
| Positive (n = 99, 41.6%) | 86 (88.6%) | 13 (11.4%) | 0.026 |
| EGFR: | |||
| Negative (n = 189, 79.4%) | 182 (96.3%) | 7 (3.7%) | |
| Positive (n = 49, 20.6%) | 38 (77.6%) | 11 (22.4%) | 0.001 |
| HER2: | |||
| Negative (n = 72, 30.3%) | 72 (100.0%) | 0 (0.0%) | |
| Positive (n = 166 69.7%) | 148 (89.2%) | 18 (10.8%) | 0.004 |
| Ki67: | |||
| Negative (n = 124, 52.1%) | 119 (96.0%) | 5 (5.0%) | |
| Positive (n = 114, 47.9%) | 101 (88.6%) | 13 (11.4%) | 0.032 |
| P53: | |||
| Negative (76, 31.9%) | 59 (77.7%) | 17 (22.3%) | |
| Positive (n = 162, 68.1%) | 161 (99.3%) | 1 (0.7%) | 0.013 |