Table 1.

Summary of the effects of antidiabetic drugs (⇑: increased, ⇓: decreased): in this table, there are summarized the principal effects of the antiglycemic drugs such as metformin, thiazolidinediones, DPP-IVi, GLP1—Ras, and SGLT2i.

Pharmacological Treatment
Metformin	Thiazolidinediones	DPP-IVi	GLP1-RAs	SGLT2i
⇓risk of hypoglycemia ⇓hyperlipidemia ⇓lower oxidative stress	⇑insulin sensitivity Control of blood pressure and hyperlipidemia ⇓infiammation ⇓cardiovascular events	⇓glycemic variability Glycemic control ⇓oxidative stress	⇓reduced glucose concentration ⇓oxidative stress and inflammation ⇓cardiovascular and adverse events Body weight controll	Improve glycemic control ⇓oxidative stress and inflammation ⇓hyperlipidemia