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Mutations in the N-terminal domain (NTD) cluster in a manner that likely modulates binding interactions. The spike glycoprotein is shown in gray with mutations present in variants of concern (VOC) shown in red, NTD VOC mutations in red, RBD VOC mutations in green, interchain contact VOC mutations in magenta, furin cleavage site mutations shown in yellow, ACE2 shown in cyan, CEACAM1 shown in orange.
