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SARS-CoV-2 variants of concern (VOC) acquire mutations in the N-terminal domain (NTD) at the sites of the highest flexibility. The cryo-EM structure of the prefusion spike glycoprotein is shown. Top panel, the NTD is shown in gray; mutations in variants of concern are shown in red; bottom panel, the NTD is colored by B-factor, indicating structural variability.
