Table 2.
ADME/T properties of all three compounds select after HTVS.
Ranges Sr. No. |
QPlogPo/w (−2.0–6.5) |
QPlogBB (−3.0–1.2) |
Mol MW (130.0–725) |
Percent Human-Oral Absorption (>80% Is High <25% Is Poor) |
FISA (7.0–330) |
PISA (0.0–450) |
QPlogHERG (Concern below −5) |
QPlogS (−6.5–0.5) |
---|---|---|---|---|---|---|---|---|
Comp 1 | 2.307 | 0.158 | 342.827 | 90.439 | 115.470 | 242.988 | −3.454 | −2.855 |
Comp 2 | 0.681 | −2.206 | 343.359 | 58.803 | 257.159 | 304.534 | −5.85 | −3.726 |
Comp 3 | 0.288 | −1.553 | 303.323 | 69.379 | 181.286 | 166.144 | −4.592 | −2.086 |