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. 2023 Jan 5;24(2):1044. doi: 10.3390/ijms24021044

Figure 7.

Figure 7

PFOS effects on pancreatic α-cells. (A) Viability of pancreatic αTC1-9 cells treated for 24 h with different concentrations of PFOS (100 pM–10 μM), as evaluated by RZ, NRU, and CFDA-AM assays. Results are expressed as % of the solvent controls (Control = 100%). (B) mRNA expression of Gcg, Gck, Glut1, Arx, MafB, and Foxo1 in control- and PFOS-treated αTC1-9 cells for 24 h. (C) Glucagon secretion in αTC1-9 cells treated for 24 h with PFOS. Data are represented as mean ± SEM of (A) n = 3, (B) n = 3, and (C) n = 3 independent experiments. * vs. Control; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by one-way ANOVA followed by Dunnett’s post hoc test or Kruskal–Wallis followed by Dunn’s post hoc test. # vs. Control; # p < 0.05, ## p < 0.01 by the Student’s t test.