Figure 9.

The biodistribution of Cy5.5-labeled HA/PMNPc in U87 tumor-bearing nude mice was determined by injecting 100 μL PBS or HA/PMNPc nanoparticles through the tail vein with (M+) or without (M−) magnetic targeting, using a magnet at the tumor area (n = 1). The in vivo imaging system (IVIS) was used for ex vivo imaging of explanted organs and tumors after 4 h (A), and quantification of distribution of nanoparticles was calculated based on fluorescence intensity in each organ as well as tumor (B).