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Chemical structures and yields of the newly synthesized lapatinib derivatives 6a–l.
| Comp. | Chemical Structure | Isolated Yield (%) |
|---|---|---|
| 6a |
|
50.3 |
| 6b |
|
83.6 |
| 6c |
|
69.1 |
| 6d |
|
70.0 |
| 6e |
|
43.7 |
| 6f |
|
61.4 |
| 6g |
|
81.7 |
| 6h |
|
69.9 |
| 6i |
|
55.9 |
| 6j |
|
83.9 |
| 6k |
|
76.5 |
| 6l |
|
79.8 |
