Table 2.

Physicochemical properties, pharmacokinetics, and lead likeness studies of the designed candidates 6a–l.

		6a	6b	6c	6d	6e	6f	6g	6h	6i	6j	6k	6l
Physicochemical properties	Molar Refractivity	132.37	137.18	141.89	146.79	121.78	126.59	131.40	136.21	150.85	155.66	160.47	165.27
	TPSA (Å2)	132.80				143.70				142.03
	Log P o/w (WLOGP)	4.50	4.89	5.28	5.67	3.83	4.22	4.61	5.00	5.43	5.82	6.21	6.60
	Consensus Log P o/w	2.82	3.16	3.47	3.81	2.36	2.74	3.00	3.23	3.55	3.86	4.24	4.60
	Water solubility	Moderately Soluble		Poorly Soluble								Insoluble
Pharmacokinetics	GI absorption	Low
	BBB permeant	No
	P-gp substrate	Yes		No
	CYP1A2 inhibitor	Yes					No
	CYP3A4 inhibitor	Yes
	CYP2C9 inhibitor	Yes
	CYP2C19 inhibitor	Yes
	CYP2D6 inhibitor	Yes									No
Lead likeness	Drug likeness (Lipinski)	Yes								No