Table 3.
% Inhibition values of the synthesized lapatinib derivatives 6a–l over EGFR and HER2 kinases at 10 µM.
Cpd | % Kinase Inhibition at 10 µM | |
---|---|---|
EGFR | HER2 | |
6a | 98.79 | 74.72 |
6b | 99.34 | 78.04 |
6c | 99.32 | 89.99 |
6d | 99.09 | 79.68 |
6e | 67.27 | 8.78 |
6f | 76.55 | 11.69 |
6g | 91.80 | 43.06 |
6h | 94.67 | 47.34 |
6i | 97.65 | 87.16 |
6j | 99.03 | 96.73 |
6k | 98.64 | 91.16 |
6l | 98.58 | 89.05 |