FIG. 1.

Sizes and chromosomal locations of E. coli K1 strain RS 218 (018:K1:H7)-specific segments identified by comparative macrorestriction mapping (38) are shown by small circles. Numbers in the circles represent sizes of K1-specific DNA segments. The sizes of two additional segments shown by arrows labeled 1 and 4, identified by subtractive hybridization (6) are currently unknown. Also shown are 11 E. coli K1 genes contributing to invasion of BMEC, indicated by squares which include K1-specific genes (e.g., ibeA, and cnf1) as well as genes which have K-12 homologues (e.g., ompA, ibeB, ibeC, and aslA).