TABLE 3.
E. coli K1 structures contributing to invasion of BMEC
| K1 structurea | Orginb | K12 homologuec | Mechanism | Reference(s) |
|---|---|---|---|---|
| ompA | Rs218/E44 | ompA (98) | Ligand-receptor | 31, 32; Wang and Kim, unpublished |
| ibeA | 10A-23 (E44ibeB::TnphoA) | None | Ligand-receptor | 20 |
| ibeB | 7A-33 (E44ibeB::TnphoA) | p77211 (97) | Ligand-receptor interaction (?) | 19 |
| ibeC | 23A-20 (E44ibeC::TnphoA) | yijP (98) | Ligand-receptor interaction (?) | 47 |
| aslA | 27A-6 (E44aslA::TnphoA) | aslA (94) | ND | 18 |
| nilA | E44, DFI | None | ND | 3 |
| nilB | E44, DFI | None | ND | 3 |
| nilC | E44, DFI | None | ND | 3 |
| ygdP | E44, DFI | ygdP (98) | ND | 3 |
| traJ | E44, DFI, STM | Noned | ND | 3, 4 |
| cnf1 | E44, STM | None | RhoA GTPase | 4 |
| cigA | E44, STM | None | ND | 4 |
| b2146 (o412) | E44, STM | o412 (42–100) | ND | 4 |
| vibO (pmgl) | E44, STM | pmgI (60–74) | ND | 4 |
| b1983 (o347) | E44, STM | o347 (49–100) | ND | 4 |
| yaiU | E44, STM | yaiU (44–100) | ND | 4 |
a
ibe, invasion brain endothelial cells; nil, newborn bovine serum-inducing loci; cig, CNS invasion gene.
b
DFI, differential fluorescence induction assay; STM, signature-tagged mutagenesis.
c
Numbers in parentheses indicate percentages of nucleotide identity of DNA sequenced.
d
Homologous to F-like plasmid R1-19.