Table 5.

Concentration–response statistics for all insecticides tested in WHO bottle assays and expected mortality or oviposition inhibition variability at the species level

Insecticide	Species	LC50 (median)	Range	LC99 (median)	Range	Variability of mortality (%)	95% Confidence interval	No. of locations
Clothianidin	Ae. aegypti	0.44	0.27–0.84	3.5	1.4–8.3	4.5	2.5–6.4	3
	Ae. albopictus	0.62	0.18–1.2	3.5	1.8–4.7	5.6	1.9–8.9	3
Flupyradifurone	Ae. aegypti	4.9	0.58–17.5	45	12–170	12	6.6–16	3
	Ae. albopictus	2.4	0.65–4.38	28	8–120	5.6	2.5–9.8	3
Metofluthrin	Ae. aegypti	0.21	0.08–0.32	0.49	0.26–0.59	6.9	4.9–10	3
	Ae. albopictus	0.12	0.049–0.19	0.37	0.14–0.60	5.8	2.8–10.0	3
Prallethrin	Ae. aegypti	1.7	1.5–2.2	13.5	6.4–19	4.0	2.6–5.1	3
	Ae. albopictus	2.4	0.5–3.9	7.6	1.6–13.7	4.8	2.9–6.4	3
Transfluthrin	Ae. aegypti	0.28	0.14–0.60	1.5	0.5–2.6	6.8	2.5–11	3
	Ae. albopictus	0.35	0.031–0.55	0.82	0.14–1.5	7.8	3.1–10	3
Chlorfenapyr	An. albimanus	1.9	1.9–2.0	6	5.9–6.0	6.6	5.9–7.5	1
	An. funestus	10	5.5–17	42	18–65	7.7	7.6–8.3	1
	An. gambiae	14	2.2–21	120	37–1.8e+04	8.5	3.0–13	4
	An. stephensi	1.5	0.38–6.6	200	16–820	3.4	1.3–5.1	2
Clothianidin	An. albimanus	0.19	0.055–0.45	1.8	0.88–46.8	6.9	4.1–9.6	2
	An. funestus	0.26	0.06–0.60	5.6	0.48–11.9	9.8	4.4–15	2
	An. gambiae	0.22	0.039–0.37	1.5	0.16–2.5	7.7	6.6–9.0	2
	An. stephensi	0.71	0.52–1.0	2.9	1.8–23.1	6.9	5.9–8.5	3
Flupyradifurone	An. albimanus	44	14–68	150	130–290	8.3	6.8–10	2
	An. funestus	11	11–11	43	43–43	2.8	1.9–4.9	1
	An. gambiae	5.9	1.0–9.3	17	6.5–22	4.4	2.1–6.4	3
	An. minimus	16	5.4–74	260	25–420	8.3	2.6–68	3
	An. stephensi	5.0	0.9–9.2	33	4–34	9.7	4.3–19	3
Transfluthrin	An. albimanus	0.13	0.003–0.30	0.60	0.017–1.1	7.3	2.0–13	3
	An. funestus	0.09	0.078–0.094	1.10	0.19–4.4	4.3	3.0–6.9	2
	An. gambiae	0.11	0.04–0.16	0.69	0.13–1.4	5.2	4.0–6.3	3
	An. minimus	0.15	0.013–0.18	0.58	0.31–0.83	1.6	1.1–2.6	2
	An. stephensi	0.10	0.025–0.27	0.44	0.095–1.2	6.5	3.5–8.1	3

Insecticide	Species	OI50 (median)	Range	OI99 (median)	Range	OI % variability	95% CI	No. of locations
Pyriproxyfena	An. gambiae	7.6	0.25–10	62	1.5–110	2.5	6.6e−10–5.9	4
	An. stephensi	10	0.74–71	800	5.1–1.6e+05	3.4	6.1e−12–7.5	3

Model outputs at the insecticide-species-institution level were generated by computing the median of all model iterations. Summary statistics for each unique insecticide and species combination were generated from the mean of institution-level outputs (i.e. the median of all model iterations). The uncertainty around LC estimates was generated from the minimum and maximum (i.e. the range) bioassay-level estimates for each insecticide-species-institution combination. The mortality/OI variability was generated from the mean of institution-level estimates (generated as the median of all model iterations) per insecticide and species. The uncertainty around the variability estimate was provided by the 95% confidence intervals of the variability estimate: if multiple institutions contributed to the estimate for the insecticide-species combination, the minimum and maximum of these values were used to represent uncertainty; if only one institution informed the estimate, the actual 95% CIs around the median estimate are shown. The number of locations is the number of institutions for each combination (even if in the same country)

LC₅₀, LC₅₀ Lethal concentration that kills 50% and 90%, respectively, of the test population

^aFor pyriproxyfen, estimates were based on the 50% and 99% oviposition inhibition (OI₅₀ and OI₉₉, respectively)