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. 2023 Jan 10;15(1):191. doi: 10.3390/v15010191

Figure 1.

Figure 1

Localization of the YFV 2016−2019 molecular signature in the NS5 MTase domain. The MTase domain of the NS5 was modeled by homology based on the sequence of YFV isolate ES-504 (GenBank: KY885000) and on the crystallographic data of YFV 17D MTase (PDB: 3EVB), MTase 2017. Mutations were inserted in PyMOL, generating MTase 2010. The models are represented in the cartoon with their respective molecular surfaces. GTP (blue) and SAM (pale yellow) binding sites are highlighted, as well as the catalytic site (purple) responsible for the methyl transfer reactions and the residues that compose the YFV 2016−2019 molecular signature.