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. 2022 Dec 24;15(1):59. doi: 10.3390/pharmaceutics15010059

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Structure of receptor tyrosine kinases depicting the extracellular portion that binds ligands and a cytoplasmic portion (red rectangle) with tyrosine kinase catalytic activity. Reprinted with permission from reference [36]. Abbreviations: ALK: anaplastic lymphoma kinase; DDR: discoidin domain receptors; EGFR: epidermal growth factor receptor; Eph: erythropoietin-producing hepatocellular carcinoma; FGF: fibroblast growth factor; IGF: insulin-like growth factor; InsR: insulin receptor; Met: mesenchymal-epithelial transition factor; MuSK: musclespecific kinase; PDGF: platelet-derived growth factor; SAM: sterile alpha motif; trk: tropomyosin receptor kinases; VEGF: vascular endothelial growth factor.