Table 3.
COX Proportional Hazards Regression Analysis, RFS.
| Variable | Univariable | p-Value | Multivariable | p-Value |
|---|---|---|---|---|
| Age | 1.0 | 0.7 | 1.0 | 0.05 |
| Sex | ||||
| Female | ref | ref | ||
| Male | 1.3 | 0.03 | 1.4 | 0.3 |
| HPV status | ||||
| Negative | ref | ref | ||
| Positive | 0.3 | <0.001 | 0.4 | <0.001 |
| Smoking category | ||||
| Never a smoker | ref | ref | ||
| 0–10 pack years | 1.5 | 0.1 | 1.4 | 0.2 |
| 10–20 pack year | 1.7 | 0.06 | 1.1 | 0.8 |
| >20 pack years | 3.1 | <0.001 | 1.7 | 0.004 |
| Unknown | 1.6 | 0.1 | 1.3 | 0.4 |
| Performance status | ||||
| PS0 | ref | ref | ||
| PS1 | 2.5 | <0.001 | 1.5 | 0.01 |
| PS2 | 4.1 | <0.001 | 2.0 | 0.01 |
| PS3 | 2.6 | 0.99 | 0.0 | 0.99 |
| Unknown | 2.2 | <0.001 | 1.6 | 0.007 |
| Tumor location | ||||
| Pharyngeal wall or unspecified location | ref | ref | ||
| Palatine tonsils | 0.7 | 0.03 | 1.3 | 0.3 |
| Lingual tonsil/Base of tongue or vallecula epiglottica | 0.8 | 0.2 | 1.3 | 0.2 |
| Soft palate, Uvula, or palatal arches | 1.1 | 0.8 | 1.1 | 0.7 |
| T stage | ||||
| T1 | ref | ref | ||
| T2 | 1.7 | 0.002 | 1.8 | 0.003 |
| T3 | 2.9 | <0.001 | 2.4 | <0.001 |
| T4a or T4b | 3.7 | <0.001 | 2.3 | <0.001 |
| Unknown | 3.6 | 0.2 | 6.9 | 0.1 |
| N stage | ||||
| N0 | ref | ref | ||
| N1 | 0.9 | 0.3 | 1.3 | 0.2 |
| N2 (including N2a, N2b, N2c) | 2.7 | <0.001 | 2.1 | 0.001 |
| N3 (including N3a, N3b) | 2.4 | 0.001 | 2.3 | 0.008 |
| Unknown | NA | NA | NA | NA |
| UICC 8th group stage | ||||
| Stage I | ref | |||
| Stage II | 1.6 | 0.01 | - | - |
| Stage III | 2.6 | <0.001 | - | - |
| Stage IV | 6.1 | <0.001 | - | - |
| Unknown | 4.0 | 0.02 | - | - |
| NLR tertile | ||||
| NLR < 2 | ref | ref | ||
| NLR 2–4 | 1.9 | 0.001 | 1.6 | 0.02 |
| NLR > 4 | 2.6 | <0.001 | 1.8 | 0.003 |