Table 3.
Effects of neurotoxins BcIII, ATF-II, ATX-II [59], CGTX-II, δ-AITX-Bcg1a, δ-AITX-Bcg1b [155], CgNa [156], Nv1, Nv5, Nv6 [17], BgII, BgIII [81,105], RTX-III [29,168], δ-SHTX-Hcr1f, and RTX-VI [168] on the Na+ currents of mammals NaV1.1–NaV1.8, insect BgNaV1, and arachnid VdNaV1 channels expressed in Xenopus laevis.
| NaTx | Voltage-Gated Sodium Channel Subtype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NaV1.1 | NaV1.2 | NaV1.3 | NaV1.4 | NaV1.5 | NaV1.6 | NaV1.7 | NaV1.8 | BgNaV1 | VdNaV1 | |
| δ-SHTX Hcr1f | + | + | - | - | - | + | n.d. | - | + | + |
| RTX-III | - | - | + | - | - | + | n.d. | - | + | + |
| RTX-VI | - | + | - | - | - | + | n.d. | - | + | + |
| BcIII | + | + | + | + | + | + | n.d. | n.d. | n.d. | n.d. |
| AFT-II | + | + | + | + | + | + | n.d. | n.d. | n.d. | n.d. |
| ATX-II | + | + | + | + | + | + | n.d. | n.d. | n.d. | n.d. |
| CGTX-II | - | - | - | - | + | + | - | n.d. | n.d. | n.d. |
| δ-AITX-Bcg1a | + | + | + | + | + | + | - | n.d. | n.d. | n.d. |
| δ-AITX-Bcg1b | - | - | - | - | - | - | - | n.d. | n.d. | n.d. |
| BgII | n.d. | + | n.d. | + | + | n.d. | n.d. | - | n.d. | n.d. |
| BgIII | n.d. | + | n.d. | + | + | n.d. | n.d. | - | n.d. | n.d. |
| CgNa | - | - | + | - | + | + | - | n.d. | n.d. | n.d. |
| Nv1 | - | - | - | - | - | - | n.d. | - | + | n.d. |
| Nv4/Nv5 | - | - | - | - | - | - | n.d. | - | - | n.d. |
n.d.—The activity of neurotoxins in relation to NaV channel subtypes was not determined.