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. 2023 Jan 13;12(2):658. doi: 10.3390/jcm12020658

Table 2.

Stress, depression, and anxiety levels among the study participants attended the National Research Center for Mother and Child Health, Astana, Kazakhstan.

Variable Total
(n = 148)
Controls (n = 78) RPL
Cases (n = 70)
t/χ2 p-Value
DASS-21 stress score continuous, mean ± SD 6.46 ± 5.11 4.83 ± 4.60 8.27 ± 5.07 t = −4.30 <0.001
DASS-21 stress severity, n (%) χ2 = 3.58 0.773
Normal 135 (91.2) 72 (92.3) 63 (90.0)
Mild–moderate 13 (8.8) 6 (7.7) 7 (10.0)
DASS-21 anxiety score continuous, mean ± SD 4.33 ± 4.48 2.74 ± 3.30 6.10 ± 4.95 t = −4.80 <0.001
DASS-21 anxiety severity, n (%) χ2 = 11.91 0.003
Normal 119 (80.4) 70 (89.7) 49 (70.0)
Mild–moderate 23 (15.5) 8 (10.3) 15 (21.4)
Severe–extreme 6 (4.1) 0 (0.0) 6 (8.6)
DASS-21 depression score continuous, mean ± SD 4.58 ± 4.83 2.92 ± 3.37 6.43 ± 5.52 t = −4.60 <0.001
DASS-21 depression severity, n (%) χ2 = 15.55 <0.001
Normal 127 (85.8) 75 (96.2) 52 (74.3)
Mild–moderate 20 (13.5) 3 (3.8) 17 (24.3)
Severe–extreme 1 (0.7) 0 (0.0) 1 (1.4)

Compared to control subjects, women with RPL had significantly higher scores of depression (p < 0.001), anxiety (p < 0.001), and stress (p < 0.001) symptoms (Table 2). Mild–moderate and severe–extreme anxiety symptoms were more pronounced in RPL cases (p = 0.003). Similarly, mild–moderate and severe–extreme depression symptoms were more pronounced in RPL cases (p < 0.001). On the other hand, stress cases were in the mild–moderate category, and were comparable between cases and controls (p = 0.773), (Table 2).