Table 2.
Cellular functions of lncRNAs in BC.
| LncRNAs | Expression in BC | Regulation | Cellular Functions | References |
|---|---|---|---|---|
| lncRNA H19 | Up-regulation | Estrogen-dependent | Proliferation, tumorigenesis, migration, invasion, and EMT | [90,92,93] |
| HOTAIR (HOX transcript antisense RNA | Up-regulation | Estrogen-dependent | Proliferation, invasion, migration, survival, epigenetic regulation, and chemotherapy resistance | [94,97] |
| LncRNA ERINA | Up-regulation | Estrogen-dependent | Proliferation, survival, and chemotherapy resistance | [101] |
| MIAT (myocardial infarction-associated transcript) |
Up-regulation | Estrogen-dependent | Proliferation, migration, invasion, chemotherapy resistance, and EMT | [102] |
| LINC00472 | Up-regulation | Estrogen-dependent | Proliferation, survival, migration, and invasion | [110,111] |
| LINC01016 | Up-regulation | Estrogen-dependent | Proliferation and survival | [114] |
| LncRNA DSCAM-AS1 | Up-regulation | Estrogen-independent | Tumorigenic processes, DNA replication, chromosome, segregation, survival, and EMT | [113,116] |
| TMPO-AS1 (TMPO antisense RNA1) | Up-regulation | Regulation of ERα expression | Proliferation and cell growth | [118] |
| MIR2052HG | Up-regulation | Regulation of ERα expression | Proliferation and cell growth | [120,121] |