Table 3.
Diagnostic clues of ATTR-CM.
| History, Examination, and Labs | Evidence of Right-Sided Heart Failure (Ascites, Lower Extremity Edema, etc.) |
|---|---|
| HFpEF | |
| Intolerance to ACEi and BB | |
| * Chronic elevation of troponin and BNP | |
| * Bilateral carpal tunnel syndrome | |
| Lumbar stenosis | |
| * Unexplained peripheral neuropathy | |
| * Autonomic dysfunction | |
| Arrhythmias or conduction system delays | |
| * Low voltage EKG | |
| Imaging | Myocardial uptake on PYP imaging |
| ECHO with biventricular hypertrophy, valve thickening, atrial septal thickening | |
| Apical sparing on longitudinal strain imaging |
* Indicates red flag signs, ACEi = angiotensin converting enzyme inhibitor, BB = beta blocker, HFpEF = heart failure with preserved ejection fraction.