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. 2023 Jan 16;24(2):1776. doi: 10.3390/ijms24021776

Figure 1.

Figure 1

Up-regulation of FGFR3 in renal pelvis tissues from Caucasian patients with urothelial carcinoma. Tissue microarray slides containing sections from Caucasian patients with renal pelvis urothelial carcinoma at stages T1–2 (n = 62), T3 (n = 17), and T4 (n = 5) were subjected to immunohistochemistry (IHC) staining with FGFR3. (A) Representative FGFR3-positive stained images from stages T1–2, T3, and T4. (B) Quantification of FGFR3 expression levels from IHC staining results (scores were from 1 to 4). Data are shown in box plots displaying 25% to 75% percentile. * indicates significance between the indicated groups. (C) Heterogeneous distribution of FGFR3 in normal renal tubular epithelium. Note that proximal renal tubules (black arrows) usually show weak FGFR3 expression (score 1+), while distal tubules (white arrowheads) in the same specimen likely display stronger FGFR3 signals (score 2+~3+).