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. 2023 Jan 16;24(2):1776. doi: 10.3390/ijms24021776

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Up-regulation of FGFR3 in renal pelvis tissues from Asian patients with upper tract urothelial carcinoma (UTUC). Renal pelvis tissues were collected from Asian patients diagnosed with UTUC at different TNM stages, including T1–2 (n = 44), T3 (n = 38), and T4 (n = 30). The formalin-fixed paraffin-embedded sections were subjected to immunohistochemistry (IHC) analysis of FGFR3 expression. (A) Representative FGFR3-positive stained images from stages T1–2, T3, and T4 and that of archived normal kidney pelvis tissues. (B) Analysis of FGFR3 IHC scoring results. (C) Statistical analysis of ethnic difference in FGFR3 expression at different UTUC stages. Data are shown in box plots displaying 25% to 75% percentiles. * indicates significance between the indicated groups.