Table 2.

Comparison between conventional emulgel and nano-emulgel.

Parameter	Conventional Emulgel	Nano-Emulgel
Thermodynamic stability	Not stable because of natural tendence of coalescence leading to sedimentation or creaming [61]	Stable–because of their smaller particle size, Brownian motion provides enough stability against gravity, preventing sedimentation or creaming [54]
Particle size	Greater than >500 nm [18]	Less than 100 nm [62]
Bioavailability	Comparatively less bioavailable than Nano-emulgel [63]	Enhanced bioavailability, attributed to small size and large surface area [64]
Permeation	Comparatively lower permeation [65]	High permeation owing to its lower particle size [54,65]
Preparation	Require high energy techniques [66]	It can be prepared either by using high or low energy techniques [20]
Systemic absorption	Very minimal	Higher compared to conventional emulgel due to the small particle size and large surface area [54]
Ability to cross BBB	Cannot cross BBB [67]	Can Cross BBB because of its small particle size [68]