Table 4.

Pre-clinical Studies on the nano-emulgel dosage form.

Active Ingredient	Composition	In Vivo Model	Route of Administration	Therapeutic Outcome	Reference
Curcumin	Oil: Labrofac PG + transcutol HP Surfactant mixture: Tween 20 + solutol HS15 Gelling agent: Carbopol 934	BALB/c mice	Topical	Psoriatic mice treated with the curcumin nano-emulgel showed faster and earlier healing than those treated with curcumin plus betamethasone-17-valerate gel	[69]
Thymoquinone	Oil: Black seed oil Surfactant mixture: Kolliphor EL + transcutol HP Gelling agent: Carbopol 940	Wistar rat	Topical	Nano-emulgel administration of thymoquinone improves its therapeutic efficiency in wound healing studies in Wistar rats	[70]
Curcumin and Resveratrol	Oil: Labrofac PG Surfactant mixture: Tween 80 Gelling agent: Carbopol	Wistar rat	Topical	Curcumin and resveratrol nano-emulgel technology revealed drastically increased curcumin and resveratrol deposition in skin layers. The in-vivo investigation revealed that the NEG formulation resulted in improved burn healing, with histological findings comparable to standard control skin. Thymoquinone nano-emulgel delivery method improves thymoquinone therapeutic effectiveness in wound healing studies in Wistar rats.	[71]
Brucine	Oil: Myrrh oil Surfactant mixture: Tween 80 + PEG 400 Gelling agent: Carboxymethylcellulose sodium	BALB/c mice and Wistar rats	Topical	Brucine-loaded nanoemulgel has shown improved anti-inflammatory and anti-nociceptive efficacy.	[72]
Curcumin	Oil: Labrofac PG Surfactant mixture: Tween 80 + PEG 400 Gelling agent: Carbopol 940	Albino rats	Topical	Curcumin nanoemulgel improved the wound-healing efficacy of curcumin compared to the conventional gel formulation.	[69]
Raloxifene hydrochloride	Oil: Peceol Surfactant mixture: Tween 20 + transcutol HP Gelling agent: Chitosan	Wistar rats	Topical	Raloxifene hydrochloride (RH) loaded nanoemulgel formulation for enhanced bioavailability and anti-anti-osteoporotic efficacy of RH. The bioavailability improved by 26-fold compared oral marketed product.	[73]
Eprinomectin	Oil: Castor oil Surfactant mixture: Tween 80 + Labrasol Gelling agent: Carbomer 940-1	Wistar rats	Topical	Naoemulgel formulation showed improved skin permeability of 1.45-fold compared to emulgel and had no skin-irritating property	[74]
Amisulpride	Oil: Maisine CC Surfactant mixture: Labrosol + transcutol HP Gelling agent: Poloxamer 407, Gellan gum	Wistar rats	Intranasal	Improved pharmacokinetic profile. The Cmax of API in brain after administering through in-situ nano-emulgel improved by 3.39-fold compared to intravenous administration of nano-emulsion.	[75]
Disulfiram	Oil: Ethyl oleate Surfactant mixture: Tween 80 + transcutol HP Gelling agent: Deacetylated gellan gum	Sprague Dawley rats	Intranasal	Improved survival rate of rats and reduced tumor progression (Glioblastoma). The survival time of in-situ nano-emulgel treated group is 1.6 times higher than control group	[76]