TABLE 1.
Panel and mouse group | Mean arthritis severity ± SDb | Carditis prevalence (no. of animals affected/total no. of animals) | Mean no. of spirochetes/μg of tissue ± SDc |
---|---|---|---|
Panel A | |||
B10.Ak-Igh-6tm1Cgn | 1.9 ± 0.6 | 6/6 | ND |
B10.Ak-Igh-6tm1Cgn | 2.6 ± 0.4 | 0/7 | ND |
Panel B | |||
B10.Ak + NMS | 0 | 9/9 | 3 ± 1 |
B10.Ak-Igh-6tm1Cgn + NMS | 1.2 ± 0.6 | 9/9 | >25 |
B10.Ak-Igh-6tm1Cgn + IMS | 0.5 ± 0.1d | 11/11e | 4 ± 0 |
Results are representative of two separate passive immunization experiments.
Values reported are the mean of tibiotarsal joint scores from individual mice for each group, as assessed on a scale of 0 to 3.
Values were rounded to the nearest integer; values equivalent to >25 spirochetes were above the cutoff for enumeration. ND, not determined.
Significantly different (P < 0.05, Fisher exact test) from value for B10.Ak-Igh-6tm1Cgn mice treated with NMS.
Carditis in this group was equivalent in severity to that observed in B10.Ak mice and B10.Ak-Igh-6tm1Cgn + NMS.