TABLE 2.
Persistence of carditis in mice deficient in αβ T cells
| Mouse strain | Carditisa at:
|
|
|---|---|---|
| Day 14 | Day 45 | |
| BALB/c × 129 | ||
| TCR α+/− | 5/5 | 0/5 |
| TCR α−/− | 4/4 | 5/5b |
| C3H | ||
| TCR α+/− | 4/4 | 0/3 |
| TCR α−/− | 4/4 | 3/3b |
| B6 | ||
| TCR α+/+ | 4/4 | 0/4 |
| TCR α−/− | 4/4 | 4/4b |
a
Carditis is reported as the number of mice with active carditis/total number of hearts examined in each group. In some cases, hearts from control and experimental groups were used for other types of analyses and were therefore not available for histopathology. These results are reflective of a total of seven separate experiments.
b
Differences in carditis prevalence at the 45-day time point were significant (P = 0.0025, Fisher exact test).