Table 4.
Results of the multivariable competing risks regression of pT1 LMS including mitoses counts after stepwise model reduction showing the subdistribution hazard ratios (SHR) of each factor with 95%-confidence intervals for each event type respectively.
| Local Recurrence (n = 164) | Distant Metastases (n = 164) | LMS Death (n = 167) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | SHR 1 | 95% CI 1 | p-Value | SHR 1 | 95% CI 1 | p-Value | SHR 1 | 95% CI 1 | p-Value |
| Tumour diameter | |||||||||
| <8 cm | — | — | |||||||
| 8–11 cm | 1.73 | 0.91, 3.30 | 0.094 | ||||||
| >11 cm | 2.00 | 1.17, 3.40 | 0.011 | ||||||
| Menopause | |||||||||
| Premenopause | — | — | |||||||
| Postmenopause | 1.93 | 1.16, 3.21 | 0.012 | ||||||
| Morcellation | |||||||||
| Non-morcellated LMS | — | — | — | — | |||||
| Morcellated LMS | 1.95 | 1.21, 3.14 | 0.006 | 0.64 | 0.37, 1.12 | 0.12 | 1.69 | 0.97, 2.95 | 0.065 |
| Mitotic index | |||||||||
| Mitoses < 15 per 10 HPF | — | — | — | — | — | — | |||
| Mitoses ≥ 15 per 10 HPF | 1.43 | 0.89, 2.28 | 0.14 | 1.84 | 1.13, 3.00 | 0.015 | 1.61 | 0.93, 2.79 | 0.092 |
| Ovariectomy | |||||||||
| No | — | — | |||||||
| Yes | 1.61 | 0.96, 2.71 | 0.071 | ||||||
| Age [10 year increment] | 1.63 | 1.23, 2.15 | <0.001 | ||||||
1 SHR = Subdistribution Hazard Ratio, CI = Confidence Interval, n = number of complete samples.