Skip to main content
. 2022 Dec 30;15(1):114. doi: 10.3390/v15010114

Figure 5.

Figure 5

SARS-CoV-2 (MA10) infection increases perivascular lymphocyte cuffing in the brains of BALB/c mice. 1-year-old female mice were infected as in Figure 3. (A) Representative H&E-stained brain images as labeled demonstrate significant perivascular lymphocyte cuffing (yellow arrowheads) at 30 days (30 dpi) post-infection SARS-CoV-2 (MA10) infected female mice. Scale bar = 20 μm. (B) Quantification of the percent of each group of animals (Saline n = 4; MA10 n = 6) with any detectable perivascular lymphocyte cuffing at various days post-infection as labeled. A total of saline n = 16 and MA10 n = 24 were included in the study. Saline n = 4; MA10 n = 6 was euthanized at each time point (each group of animals), and all mice were undergone for histological analysis. Graphs represent only the percent of each group of animals that showed positive for histopathological symptoms of perivascular lymphocyte cuffing. Chi-Square trend analysis shows a significant change in the portion of mice with detectable perivascular lymphocytic cuffing over time only in SARS-CoV-2 (MA10)-infected mice.