Figure 6.
Intranasal administration of SARS-CoV-2 (MA10) upon accumulation in the mice upregulates Ccl2 and Il-1β, activates microglia, induces perivascular lymphocyte cuffing, promotes astrocyte accumulation, triggers a loss of tight junction protein claudin-5. These neuroinflammatory events mediate cerebrovascular pathology in the mice infected with SARS-CoV-2 (MA10). (https://biorender.com/ accessed on 30 October 2022).