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. 2022 Dec 30;15(1):114. doi: 10.3390/v15010114

Figure 6.

Figure 6

Intranasal administration of SARS-CoV-2 (MA10) upon accumulation in the mice upregulates Ccl2 and Il-1β, activates microglia, induces perivascular lymphocyte cuffing, promotes astrocyte accumulation, triggers a loss of tight junction protein claudin-5. These neuroinflammatory events mediate cerebrovascular pathology in the mice infected with SARS-CoV-2 (MA10). (https://biorender.com/ accessed on 30 October 2022).