Figure 8.
Immunomodulatory effect of Lactiplantibacillus plantarum CRL681, CRL1506 or TL2677 in mice in response to enterotoxigenic Escherichia coli (ETEC) challenge. Mice were orally treated with L. plantarum CRL681, CRL1506 or TL2677 (108 cells/mouse per day for 5 consecutive days) and then challenged orally with ETEC F4 strain (109 cells). Mice with no lactobacilli treatment and challenged with ETEC were used as controls. The intestinal levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6, IL-10, chemokine KC (or CXCL1), and monocyte chemoattractant protein 1 (MCP-1) were determined two days after the challenge with ETEC. Values are means ± SD. Bold letters indicate significant differences when compared to the ETEC control group (p < 0.05).