Table 2.

Multiple linear regression models of principal component score 1 (PC1) derived from metabolites with significantly different fold changes after the OGTT between T2D and control subjects vs. insulin sensitivity and obesity.

	Standardized Beta	p-Value	95% CI	R2
Model 1
GluAUC	−0.736	<0.001	[−0.30, −0.13]
HOMA-IR	−0.010	0.950	[−0.46, 0.43]
BMI	−0.222	0.098	[−0.36, 0.03]
				0.61 ***
Model 2
HbA1c	−0.463	0.003	[−0.30, −0.07]
HOMA-IR	−0.289	0.068	[−0.85, 0.03]
BMI	−0.132	0.379	[−0.32, 0.12]
				0.47 ***

PC1: proportion of variance = 46.5%. Models are adjusted for sex and age. CI, confidence interval for unstandardized coefficient (lower bound, upper bound); Glu_AUC, glucose area under the curve; BMI, body mass index; HbA1c, glycosylated hemoglobin. Bold values indicate statistical significance. *** p < 0.001.