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. 2023 Jan 13;24(2):1607. doi: 10.3390/ijms24021607

Figure 2.

Figure 2

Structures of GPX4-related molecules mentioned in the article. (A) (1S-3R)-RSL3, or RSL3, the first described Class II inhibitor that directly targets GPX4 to trigger ferroptosis. (B) (1R-3R)-RSL3, a diastereomer of (1S-3R)-RSL3, which loses its HRAS selectivity. (C,D) ML162 and ML 210, the direct GPX4 inhibitors. (E) FIN56, a Class III ferroptosis inducer, mainly triggers ferroptosis through cellular depletion of GPX4. (F,G) FINO2, a Class IV inducer that does not directly inhibit GPX4. (H) Erastin, a classic Class I inducer that function by inhibiting system xc− instead of affecting GPX4 directly.