Table 2.

β-Adrenergic medicinal chemistry leads.

Molecule	Name	Primary Targets	Secondary Targets	References
25	Amibegron	β3		[56,57]
26	Arbutamine	β		[58,59,60]
27	Bambuterol	β		[61]
28	Batefenterol	β2	Muscarinic M2, M3	[62,63]
29	BI-167107	β2		[64]
30	BRL 37344 sodium	β3		[65]
31	Brombuterol	β		[66]
32	Bromchlorbuterol	β		[67]
33	CL 316243	β3		[68,69]
34	Clenproperol	β2		[70]
35	Clorprenaline	β2		[71]
36	Denopamine	β1		[72]
37	Dopexamine	β2		[73]
38	Epanolol	β		[74]
39	Fenoterol	β2		[75,76]
40	Guanfacine	β1	α2-adrenoceptors	[77]
41	HOKU-81	β2		[78]
42	Imoxiterol	β		[79]
43	Indacaterol	β		[80]
44	Isoprenaline	β		[81,82,83]
45	Isoxsuprine	β	N-methyl-D-aspartate (NMDA)	[84]
46	KUC-7322	β3		[85]
47	KUL-7211	β		[86]
48	L748337	β3		[87]
49	L755507	β3		[88]
50	Levalbuterol	β2		[89]
51	Lubabegron	β		[90]
52	LY377604	β3		[91]
53	Mapenterol	β2		[92]
54	Metaproterenol	β2		[93,94]
55	Mirabegron	β3		[95]
56	N-5984	β3		[96]
57	Naminterol	β2		[97]
58	Navafenterol	β2	Muscarinic M3	[98]
59	Octopamine	β		[99,100]
60	Olodaterol	β2		[101,102]
61	Pamatolol	β		[103]
62	PF-610355	β2		[104,105]
63	Phenylethanolamine A	β		[106]
64	Pronethalol	β		[107]
65	Reproterol	β2	Phosphodiesterase (PDE)	[108]
66	Ritodrine	β2		[109]
67	Ro 363	β1		[110]
68	Rotigotine	β	α2-adrenoceptor, 5-HT1A, Dopamine D2, D3, D4, D5	[111]
69	Salbutamol	β2		[112]
70	Salmeterol	β2		[113]
71	SB-206606	β3		[114]
72	Sibenadet	β	Dopamine D2	[115]
73	Solabegron	β3		[116]
74	Sulfinalol	β		[117]
75	Synephrine	β	α-adrenoceptor	[118]
76	Talibegron	β3		[119]
77	TD-5471	β2		[120]
78	Terbutaline	β2		[121,122]
79	Tulobuterol	β2		[123]
80	Vilanterol	β		[124,125]
81	Zinterol	β2		[126]
82	ZK-90055	β2		[127]
83	-	β3		[128]
84	-	β3		[129]